16. Frank M, Hendricks S, Johnson S, Wiesler JL Burke WJ. Antidepressants increase the activity of natural killer cells: in vivo and in vitro. Neuropsychobiology 1999, 39 (1) :18-24.8. Fernandez-Cruz E, Gelpi E, Longo N, Gonzalez B, de la Morena, MT, Montes, MG, Rosello J, Ramis I, Suarez A, Fernandez, A. Increased synthesis and production of prostaglandin E2 by monocytes from drug addicts with AIDS. AIDS 1989, 3: 93-96.
People with intact immune function are relatively invulnerable to pathogens, compared with those with defective function. is rarely mentioned because of a lack of immunity, although indices of immune function indicate that so.17In a study of 405 gay and bisexual men with HIV, those who reported being depressed throughout the period study of eight were two thirds more likely to die than those who were never significantly depressed.18
Collaborative trial shows that lithium is immunostimulant, antiviral, antibacterial and immunostimulant 11antidepressants, antiviral, antibacterial from 0.1 to 4 anti-parasitic, fungicidal properties.12-15 Lithium is often effective for bacterial infections of the skin, ulcers and mouth disease genital 11antidepressants for canker sores, cold sores and genital herpes.11Tuberculosis, now the number one killer of HIV infection, has developed resistance to standard treatment. Their ranking showed that all were taking monoamine oxidase isoniazid or iproniazid, an observation which has developed antidepressant therapy. If antituberculotics double as antidepressants, antidepressants should probably double antituberculotics? The antimalarial properties of antidepressants in vitro are supported by many studies.12When added antiretrovirals, antidepressants can reduce HIV viral load undetectable.16 The authors attribute this to the members, apparently oblivious of the antiviral properties of antidepressants. The benefit of immunostimulation is its non-specificity, a stimulated immune system indifferent to antigenicity.
20. Evans DL, Lynch KG, Benton T, Dube B, courgettes Tustin NB, Lai JP, Metsger D, Douglas SD reuptake inhibitor of serotonin and substance P antagonist improves innate immune cells to natural killer virus immunodeficiency virus / syndrome Acquired immunodeficiency. Biol Psychiatry 2008 May 1:63 (9) :899-905. Epub 2007 Oct 22.
19. Morrison, Chiappini MS, Brinker-Spence P, Job C, Mercer DE, Wang YL, Cruess D, Dube B, Dalen EA, Brown T, Bauer R, Petitto JMAssociation of depression with viral load, CD8 T cells and natural killer cells in HIV-infected women. Am J Psychiatry. October 2002, 159 (10) :1752-9.
18. Lieb, J., ‘Strengthening the immune system to destroy the virus.’ (And bacteria, parasites and fungi). 2009, Amazon
9. Human glycoprotein of human immunodeficiency virus (gp120) induction of monocyte arachidonic acid metabolites and interleukin 1. Proc Natl Acad. Sci USA 1989, 86:621-625.
2. Lieb J. ceremony and other disorders of immunity in patients taking monoamine oxidase. Int J Immunopharmacol 1983; 5 (4): 353-357.
4. Murphy D, Donnelly C, Moskowitz J. Inhibition by lithium of the effects of prostaglandin E1 and norepinephrine on the production of cyclic adenosine monophosphate in human platelets. Clin Pharmacol There 1973, 14 (5) :810-814.
Stimulate the immune system is not able to efficiently carry out a desirable approach to overcome pathogens. This stimulation is represented as unavailable, but the truth of the immunostimulatory properties of lithium and antidepressants have been documented for many years ago.1-4 A request has strengthened therapeutic when the mechanism is unknown. Prostaglandins, when produced excessively, press all the components of the immune system and induce microbial replication. Everywhere in contact with arachidonic acid, an envelope glycoprotein powerfully converts this precursor of prostaglandin E2, depressing immune function and promotion of viral replication, excessive prostaglandin E2 a leading candidate for the immunosuppression that is the mark of 0.5 – 7Antidepressants inhibit the synthesis of prostaglandin E2, antagonize its actions, and to stimulate the primary prostaglandin-degrading enzyme.8 10
17. Mayne TJ, Vittinghoff E, Chesney MA, Barrett DC, Coates TJ. Depressive and survival among gay and bisexual men infected with HIV. Arch Intern Med October 28, 1996, 156 (19) :2233-8.
Forty years ago, prostaglandins have been shown to regulate immune function, and lithium and antidepressants to inhibit prostaglandins. Gradually, prostaglandins were found to regulate all aspects of HIV replication and HIV to stimulate the production of prostaglandin E2, a greater degree than other viruses. This prostaglandin, when produced excessively, is thought to be responsible for the immunosuppression that is the hallmark of AIDS. Twenty-five years, I thought that lithium and antidepressants could be used as heavy artillery against HIV, but when the battery has failed to improve AIDS patients in two small clinical trials, has come to focus on antidepressants for this purpose .19, 20.21
5. Lee R. The influence of psychotropic drugs on prostaglandin biosynthesis. Prostaglandins 1974; 5 (1) :63-68.
10. Dumais N, Barbeau B, Olivier M, Tremblay MJ. Prostaglandin E2 up regulate the activity of genes of HIV-1 long terminal repeat-driven T cells via NF-kappa B-dependent and – independent signaling pathways. J Biol Chem 1998, 273 (42): 27306-27314
11. Dutta P, Pinto J, R. Rivlin antimalarial properties of imipramine and amitriptyline. J Protozool 1990, 37 (1): 54-58.
21. Benton T, Lynch K, Dube, B, DR zucchini, Tustin NB, Lai JP, Metsger DS, Blume J, Douglas SD, Evans DL. Serotonin selective reuptake inhibitor suppression of infectivity of HIV replication Psychosom Med 14 October 2010
Warning: This article is for educational purposes. All treatment decisions to be made with a doctor
6. Manku MS, Horrobin DF. Chloroquine, quinine, procaine, quinidine and clomipramine are prostaglandin agonists and antagonists. Prostaglandins 1976, 12: 789-801.
1. Lieb J. delivery of herpes virus infection and immune systems with lithium carbonate: Inhibition of prostaglandin E1 synthesis by lithium may explain its antiviral, immunopotentiating, and antimanic properties. Biol Psychiatry 1981; 695-698.